Glomerular Endothelial Cells in Uranyl Nitrate-induced Acute Renal Failure in Rats
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چکیده
منابع مشابه
Glomerular endothelial cells in uranyl nitrate-induced acute renal failure in rats.
In uranyl nitrate (UN)-induced acute renal failure (ARF) glomerular ultrafiltration coefficient (K(f)) decreases because of unknown reasons. Since transport of water across the glomerular capillary wall occurs predominantly extracellularly through the endothelial fenestrae (EF), a reduction in the diameter and/or the density of EF can reduce the extracellular filtration area and the glomerular ...
متن کاملThe Mechanism of Acute Renal Failure after Uranyl Nitrate ROLAND
Portions of this work were presented at the Annual Meeting of The American Federation for Clinical Research, Atlantic City, N. J., 5 May 1974. Received for publication 21 June 1974 and in revised form 18 November 1974. dose UN (0.047±0.013) and high dose (0.024±0.003 nVs/g kidney wt/mm Hg). Therefore UN decreases GFR by two mechanisms: (a) tubular damage leading to back-diffusion of solutes and...
متن کاملExperimental acute renal failure induced by uranyl nitrate in the dog.
The diminished glomerular filtration rate observed in previous studies of acute renal failure induced by uranyl nitrate has been ascribed to backflow of glomerular filtrate through necrotic tubular epithelium, since renal blood flow was essentially normal. Renal blood flow (xenon washout) and renal function were studied serially for 96 hours after the administration of uranyl nitrate (10 mg/kg,...
متن کاملestimation of glomerular volume in rats with glycerol-induced acute renal failure
introduction: the use of stereological methods in evaluation of volume changes in vital organs such as kidney is very important. in this study, the volume of glomeruli in glycerol-induced acute renal failure in rats was determined. methods: 48 sprague-dawley male rats were divided into 2 groups (1control, 1experiment). experimental group was injected 10ml/kg of 50% glycerol intramuscularly, whi...
متن کاملPharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with uranyl nitrate-induced acute renal failure.
Because the physiological changes that occur in patients with acute renal failure could alter the pharmacokinetics of the drugs used to treat the disease, the pharmacokinetics of DA-1131, a new carbapenem antibiotic, were investigated after 1-min intravenous administration of the drug (50 mg/kg of body weight) to control rats and rats with uranyl nitrate-induced acute renal failure (U-ARF rats)...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1980
ISSN: 0021-9738
DOI: 10.1172/jci109641